Analysis of Factors Affecting Internal Dryness of Effervescent Tubes

The effervescent tablet tube is a special packaging for effervescent tablets. The effervescent tablet contains an effervescent disintegrant, which is easily decomposed when exposed to moisture. Therefore, the moisture-proof performance of the packaging is required to be high. So what are the factors that affect the internal dryness of the effervescent tube?
There are many factors that affect the dryness inside the effervescent tube. The common ones are as follows:

1. The water content of the effervescent tablet itself. The conventional preparation methods of effervescent tablets include wet granulation, dry granulation, and direct compression. Among them, wet granulation is difficult to ensure that the tablet is completely anhydrous, so the tablet itself will contain a certain amount of water, but this Moisture is minimal.

2. The performance of the packaging materials used in the product. Whether the material used for the effervescent tube has good water-blocking performance will also affect its internal dryness. Generally, the bottle body of the effervescent tube is made of polypropylene, which has good water-blocking performance and can prevent the external water vapor. intrude.
3. The degree of sealing of the packaging. The degree of sealing of the effervescent tube will also affect the dryness of its interior, which mainly examines whether the cap and the bottle body can be closely matched to achieve a good sealing effect.

4. The hygroscopic ability of the desiccant. In order to ensure the dryness inside the package, a desiccant is generally placed inside the effervescent tube, but the hygroscopic performance of the desiccant and whether the dosage can ensure the dryness of the internal environment are issues that pharmaceutical companies need to pay special attention to.
The above are several common factors that affect the dryness inside the effervescent tube. In addition, the temperature and humidity during filling of effervescent tablets, as well as the environment and climatic conditions during transportation and storage of the product, will also affect the dryness inside the package.